HORDB

ID: hor002376
Uniprot ID: O62820
Protein name: Motilin
Gene name: MLN
Organism: Bos taurus (Bovine)
Family: Motilin family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Bos (genus), Bovinae (subfamily), Bovidae (family), Pecora (infraorder), Ruminantia (suborder), Artiodactyla (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity; GO:0031788 motilin receptor binding
GO BP: GO:0007165 signal transduction
GO CC: GO:0005576 extracellular region

Sequence: FVPIFTYGEVRRMQEKERYKGQ
Length: 22
Propeptide: MLSRKATAVLLAVHAAAMLASQTEAFVPIFTYGEVRRMQEKERYKGQKKSLSVQQRSEEVGPVDPTEPWEEKQEVIKLTAPVEIGMRMNSRQLEKYQATLEGLLREVLPPSRNAQ
Signal peptide: MLSRKATAVLLAVHAAAMLASQTEA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle.
Mechanism: NA
Cross BBB: NA
Target: MLNR
Target Unid: F1MPN9
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-P83860-F1.pdb

hor002376_AF2.pdb

hor002376_ESM.pdb

Mass:	313691	Formula:	C125H193N35O34S
Absent amino acids:	ACDHLNSW	Common amino acids:	ER
pI:	9.93	Basic residues:	5
Polar residues:	5	Hydrophobic residues:	5
Hydrophobicity:	-109.55	Boman Index:	-6703
Half-Life:	1.1 hour	Half-Life Yeast:	3 min
Half-Life E.Coli:	2 min	Aliphatic Index	44.09
Instability Index:	3509.09	Extinction Coefficient cystines:	2980
Absorbance 280nm:	141.9